During the COVID-19 pandemic the situation in Ivory Coast was characterized by a deep mistrust against the hygienic measures of the government as well as against the vaccines that were offered as a means to protect oneself against infection with the virus. The chapter focuses on attitudes of Ivorians who define themselves as Muslims toward COVID-19 and tries to find out if they share into the rejection of vaccines and what religion has to do with their attitude. A small study done with qualitative empirical methods, of course, can never be representative for the whole Islamic population in Ivory Coast. Yet, the interviews grant a glimpse into the attitudes toward vaccines and into the relationship between religion, health and politics. The research results in the preliminary impression that socio-cultural and political factors are more important than religion. Significant differences between social groups within the Islamic community become clear.