The association of leptin secretion with cognitive performance in patients with eating disorders

Faculty/Professorship: Clinical Psychology and Psychotherapy  
Author(s): Wollenhaupt, Carina; Wilke, Leonhard; Erim, Yesim; Rauh, Manfred; Steins-Löber, Sabine  ; Paslakis, Georgios
Title of the Journal: Psychiatry Research
ISSN: 0165-1781
Publisher Information: Amsterdam [u.a.] : Elsevier
Year of publication: 2019
Issue: 276
Pages: 269-277
Language(s): English
DOI: 10.1016/j.psychres.2019.05.001
This study is an investigation of neuropsychological performance in patients with anorexia nervosa, bulimia nervosa, and binge eating disorder and hormonal secretion patterns for ghrelin, leptin, insulin, and glucose. An oral glucose tolerance test (OGTT) was performed in a cohort of n = 30 female patients suffering from eating disorders as well as n = 20 control females. All participants underwent the Wisconsin Card Sorting Test (WCST), the Trail Making Test (TMT), and a go/no-go task using food vs. neutral stimuli. Patients with anorexia nervosa differed from controls in their leptin response to the OGTT. While the four groups under investigation did not differ in neuropsychological performance, we found leptin responses to the OGTT to be associated with performance in the food-specific go/no-go task. These preliminary results may indicate a putative association between leptin concentrations and neuropsychological performance, particularly in measures of inhibitory control. Further studies investigating the role of leptin in impulsive behaviors in eating disorders would be useful.
Keywords: Eating disorder, Oral glucose tolerance test, Ghrelin, Leptin, Neuropsychological performance
Peer Reviewed: Ja
International Distribution: Ja
Type: Article
Year of publication: 26. July 2019