The paper shows the results of archaeological surveys carried out at the site where the Spaniards founded the Fortress of Santo Tomás de Jánico in 1494, during the initial colonization of Hispaniola. With the objective to identify structural remains of the fortress, and to validate ideas of a second occupation of this enclave, as well as searching for new information about the materials used in its construction, technical means such as ground penetration radar (GPR), metal detector, total station (TS) and drones were used. A three-dimensional model of the surface of the archaeological site was created from the photogrammetric surveys, in order to provide a new topographic map. From archaeological field surveys in the vicinity of the fortress nine new indigenous archaeological sites were registered as well.