Innovation is important for a firm`s success and has been shown to be essentially influenced by absorptive capacity (ACAP). ACAP has been conceptualized by various dimensions that, in turn, rest on diverse antecedents. Currently, little is known about the impact of information systems (IS) on these dimensions of ACAP. Drawing on the complementarity argument that IS will only render an effect if jointly employed with complementary organizational capabilities, we develop a research model that elucidates the interplay of organizational capabilities, ACAP, and their effect on innovation success. In particular, we deal with combinative capabilities by splitting these organizational capabilities into mechanisms and control modes. Addressing calls in the literature and from industry, this model contributes to our understanding of how to build and improve a firm’s innovation capabilities by theorizing combinative capabilities and IS as antecedents of ACAP.