Advancing virtual reality technologies are enabling real-time virtual-face to virtual-face communication. Hand tracking systems that are integrated into Head-Mounted Displays (HMD) enable users to directly interact with their environments and with each other using their hands as opposed to using controllers. Due to the novelties of these technologies our understanding of how they impact our interactions is limited. In this paper, we investigate the consequences of using different interaction control systems, hand tracking or controllers, when interacting with others in a virtual environment. We design and implement NASA’s Survival on the Moon teamwork evaluation exercise in virtual reality (VR) and test for effects with and without allowing verbal communication. We evaluate social presence, perceived comprehension, team cohesion, group synergy, task workload, as well as task performance and duration. Our findings reveal that audio communication significantly enhances social presence, perceived comprehension, and team cohesion, but it also increases effort workload and negatively impacts group synergy. The choice of interaction control systems has limited impact on various aspects of virtual collaboration in this scenario, although participants using hand tracking reported lower effort workload, while participants using controllers reported lower mental workload in the absence of audio.