The COVID-19 pandemic has induced various changes in the daily lives of expatriate employees. However, we lack insight into how this population experienced the quality of life under pandemic conditions and the predictors and consequences of such experiences. In this study, we adopted a person-centered approach to investigate the diverse ways in which the pandemic changed expatriates’ quality of life and to identify the risks, protective factors, and outcomes of their perceptions. We employed quantitative data from 707 expatriates residing in three European countries and latent class analysis to reveal four ways in which they discerned the impact of the pandemic on their quality of life, namely “negative”, “slightly positive”, “moderately positive”, and “neutral”. The perceived changes in quality of life determined their intention to stay in the host country and organizations, readiness for international relocation and mobility, and career resources. Further, gender, marital status, expatriation mode, community embeddedness, and personal initiative played a role in how expatriates perceived the impact of the pandemic on quality of life. Based on the results, we have provided several implications for organizations in crises such as the pandemic, as part of their international human resource management policies.