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Accuracy and precision of fixed and random effects in meta‐analyses of randomized control trials for continuous outcomes
Gnambs, Timo; Schroeders, Ulrich (2024): Accuracy and precision of fixed and random effects in meta‐analyses of randomized control trials for continuous outcomes, in: Research synthesis methods, Hoboken, NJ [u.a.]: Wiley, Jg. 15, Nr. 1, S. 86–106, doi: 10.1002/jrsm.1673.
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Title of the Journal:
Research synthesis methods
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Year of publication:
2024
Volume:
15
Issue:
1
Pages:
Language:
English
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Abstract:
Meta-analyses of treatment effects in randomized control trials are often faced with the problem of missing information required to calculate effect sizes and their sampling variances. Particularly, correlations between pre- and posttest scores are frequently not available. As an ad-hoc solution, researchers impute a constant value for the missing correlation. As an alternative, we propose adopting a multivariate meta-regression approach that models independent group effect sizes and accounts for the dependency structure using robust variance estimation or three-level modeling. A comprehensive simulation study mimicking realistic conditions of meta-analyses in clinical and educational psychology suggested that imputing a fixed correlation 0.8 or adopting a multivariate meta-regression with robust variance estimation work well for estimating the pooled effect but lead to slightly distorted between-study heterogeneity estimates. In contrast, three-level meta-regressions resulted in largely unbiased fixed effects but more inconsistent prediction intervals. Based on these results recommendations for meta-analytic practice and future meta-analytic developments are provided.
Keywords: ; ; ; ;
effect size
meta-analysis
missing value
randomized control trial
robust variance estimation
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Article
Activation date:
March 21, 2024
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https://fis.uni-bamberg.de/handle/uniba/94440