That Africa has been hardest hit by the HIV pandemic is beyond doubt or debate. What Africa has done in response still needs documentation and analysis. Although AIDS related deaths have decreased significantly since the introduction of anti-retroviral therapy and its free roll out by many African governments, the pandemic remains a cause for concern and worthy of attention. HIV remains a serious health and developmental challenge. What role has Africa played over the past more than 30 years of living with HIV & AIDS? This is the question this chapter attempts to address by focusing on the work of one African man, Ezra Chitando, of the World Council of Churches and the University of Zimbabwe. Specifically, the chapter considers how, through socially engaged scholarship, he has rallied African biblical scholars, theologians, philosophers, religious studies scholars, and all other stakeholders (especially focusing on men) to respond to HIV.