The advent of COVID-19 and the subsequent array of fast-tracked vaccination against the disease gripped many people with fear and relief and the same time. Various perceptions emerged as people were in a dilemma as to how they should manage and put under control the pandemic. As the vaccinations were rolled out to people, different viewpoints erupted. The church also expressed its perceptions on the vaccines. The church had a myriad of reactions in so far as the rolling out of vaccinations was concerned. The mainline churches saw no problem in following the view and plan of the government. Some Pentecostal churches were treating it as accepting the mark of the beast. Other church denominations used quiet diplomacy on the issue of vaccination. Some African Initiated Churches opted for prayer rather than vaccines on the issue of COVID-19. It is light of this that this chapter intends to give a critique of the responses of African Initiated Churches to COVID-19 vaccination in Zimbabwe. The chapter uses the qualitative approach to glean the efficacy and non- efficacy of prayers for protection against the pandemic. Focus group discussions, personal observations, interviews and document analysis were used to glean data. The chapter focuses on how African Initiated Churches were placing importance on prayers for protection against the pandemic instead of embracing the COVID-19 vaccines that the nation was rolling out.