When the COVID-19 pandemic came, it killed millions of people and ravaged national economies, leaving many societies more vulnerable than before the Pandemic. However, beyond economic and social complexities, the Pandemic has also left in its wake religious and theological controversies. For example, in Malawi, the COVID-19 vccine has polarised the religious community, with others accepting it as God-given while others reject it as Satanic. This chapter examines Romans 14:1-12 in the context of the COVID-19 vaccine controversy in Malawi. It argues that in contexts like Malawi, where sharp theological differences over the COVID19 vaccine sub-sist, Paul’s representation of weak and strong Christians in Romans 14:1-12 provides a framework through which Christians can negotiate the polar-ising effect of the COVID-19 vaccine. After examining the meaning of Romans 14:1-12 in the context of Paul Greco-Roman auditors, the chapter explores the implications of Paul’s ‘strong and weak’ framework for a local Christians’ response to the COVID-19 vaccine controversy in Malawi. Through this analysis, the chapter contributes to the body of knowledge on the effects of the COVID-19 pandemic in Malawi and, by implication, the relationship between religion and health in Africa.