COVID-19 is a global pandemic that has send out shivers and quivers to all countries of the world, including the so-called First World Economies. Everyone is affected by COVID-19, but the impact is direct and indirect to public health emergencies and disproportionally on the most vulnerable. However, beyond health outcomes the wider impacts of the pandemic, including increased burdens of care giving, disrupted livelihoods, increased malnutrition and an increase in violence, have significantly and disproportionately affect women and girls in Zimbabwe. This chapter’s objectives are to discuss key considerations on the public health response to the pandemic and its intersection with ethics in Zimbabwe. This chapter uses the qualitative research methodology of reviewing existing data through a desk research analysis method. The findings are that COVID-19 has severely affected women than men and has attracted dilemmas in the context of ethics in Zimbabwe