The economic disenfranchisement of women in Sub-Saharan Africa is influenced by a variety of intersecting factors that create barriers to development and full participation in the economy. Addressing these factors requires a multifaceted approach. In this chapter, I address the issue of patriarchal biblical interpretation and male hegemony. Scholars have long argued that androcentric biblical interpretations have prioritized and advanced male agendas and positions. In so doing, women’s roles, perspectives, and positions in society are deliberately cast as secondary to that of men, reinforcing patriarchy. Consequently, the subordinate and subservient positions of women have become a taken for granted norm. Following a qualitative research design using interpretive analysis of the work of Ezra Chitando and African Women’s Theology, I contend that androcentrism, patriarchy and dominant and toxic masculinities, sanctioned by male hegemony and biblical interpretation, play a pivotal role in the economic disenfranchisement of women in Sub-Saharan Africa.