Africa has been battling a myriad of injustices, some are externally originated and influenced, while others are internally originated and influenced. This chapter focuses on gender injustice, racism, sexuality and xenophobia, challenges that do not always attract the most attention especially in the face of persisting conflicts and poverty in Africa. Using an intersectional approach, this chapter acknowledges the role played by Ezra Chitando in drawing attention to the collective contributions of these challenges in increasing the vulnerability of women. The chapter demonstrates that based on the work of Chitando, whether intentionally or unintentionally, an intersectional approach is best suited to address the challenges that have contributed to avoidable deaths of women and men. The intersections have led to the failure to acknowledge the contributions of women to sustainable social transformation and to fragmented quests for diversity, inclusion and belonging for the most vulnerable groups in African societies. To mitigate against the power of intersections, this chapter calls African women theologians to embrace an intersectional approach to confront the intersecting marginalising forces, as well as to guard against inverted patriarchy in the African Women’s quest for holistic liberation.