Successful collaboration between clinicians is particularly relevant regarding the quality of care process. In this context, the utilization of hybrid intelligence, such as conversational agents (CAs), is a reasonable approach for the coordination of diverse tasks. While there is a great deal of literature involving collaboration, little effort has been made to integrate previous findings and evaluate research when applying CAs in hospitals. By conducting an extended and systematic literature review and semi-structured expert interviews, we identified four major challenges and derived propositions where in-depth research is needed: 1) audience and interdependency; 2) connectivity and embodiment; 3) trust and transparency; and 4) security, privacy, and ethics. The results are helpful for researchers as we discuss directions for future research on CAs for collaboration in a hospital setting enhancing team performance. Practitioners will be able to understand which difficulties must be considered before the actual application of CAs.