Conflicts are normally complex, multidimensional, and dynamic, making it difficult to propose a simple, easy solution. The leader’s capacity to see warning signs that affect the healing of relationships and respond appropriately to bring about real change in people goes beyond resolution to transformation. This chapter explores how Esther employed conflict transformational strategies after Haman’s edict ignited social conflict among the Jews to ensure empowerment that made the Jews triumph over the Persians. It looks at Esther’s interactive processes that led to empowered relationships, reconciled tensions, and redefined interests, and shows how conflict transformation resonates with African traditional forms of conflict interventions. The approach is intercultural applied Bible studies, bearing in mind that interpretation across cultural boundaries has to be conceived as a multiple-way activity that is sensitive to both the culture of the Bible and the culture of the reader. The Ghanaian-Akan culture is used for the mutual engagement of conceptions and viewpoints. It proposes that Esther’s approach can serve as a model for traditional leaders in the Akan traditional setting of Ghana to ensure transformed relationship during conflict situations.