The study documents how climate change and environmental destruction (CCED) shape youth’s lives in ecologically precarious rural communities in Rwanda, Malawi and Colombia, and how education systems recognize and respond to these pressures. Examining the complex interconnectedness of local and global economic, social, ecological and health systems, the objective is to build towards a transformative model of planetary health education that is rooted in marginalized youth’s experiences of CCED and transdisciplinary thinking about local and global solutions that can potentially be used across ecological contexts and national boundaries.