Pfeiffer, ElisaElisaPfeifferGarbade, MaikeMaikeGarbadeBeer, RenéeRenéeBeerBirgersson, AnetteAnetteBirgerssonCabrera, NatalieNatalieCabreraCohen, Judith A.Judith A.CohenDeblinger, EstherEstherDeblingerGjini, RafaelaRafaelaGjiniKirsch, VeronicaVeronicaKirschKostova, ZlatinaZlatinaKostovaLarsson, MichaelMichaelLarssonMannarino, AnthonyAnthonyMannarinoMoffitt, GavinGavinMoffittOnsjö, MarjaMarjaOnsjöOstensjo, TaleTaleOstensjoVikgren, AnnaAnnaVikgrenWeyler, HannaHannaWeylerKlymchuk, VitaliiVitaliiKlymchukSachser, CedricCedricSachser0000-0002-9353-79362025-08-262025-08-2620251778-35850924-9338https://fis.uni-bamberg.de/handle/uniba/109833Background The large-scale Russian invasion of Ukraine in early 2022 resulted in a humanitarian crisis with hundreds of thousands of children exposed to traumatic events. To date, trauma-focused evidence-based treatments (EBTs) for children and youth have not been systematically evaluated and implemented in Ukraine. This study aims at evaluating 1) the feasibility of a training program for Ukrainian therapists on Trauma-Focused Cognitive Behavioural Therapy (TF-CBT) and 2) the feasibility and effectiveness of the treatment for children, youth, and their families in and from Ukraine during the ongoing war. Methods The project “TF-CBT Ukraine” was implemented between March 2022 and May 2024, in close collaboration with local and international partners. Therapists completed questionnaires before/after the training, and patients were asked to complete a measure on PTSD before and after treatment. Results Altogether 138 therapists started the training program and 44.9% were certified as TF-CBT therapists. The program completers reported overall high satisfaction with the training program, a positive change in their attitude towards EBTs and trauma-related knowledge gain. The patients (age 3–21, 37% male) reported significant improvement in symptoms of PTSD at the end of treatment with large pre-post effect sizes for DSM-5 PTSD (dselfreport = 2.36; dcaregiverreport = 2.27), ICD-11 PTSD (dselfreport = 1.97; dcaregiverreport = 1.77), ICD-11 CPTSD (dselfreport = 2.04; dcaregiverreport = 1.99), and DSM-5 pre-school PTSD (dcaregiverreport = 3.14). Conclusions The results of this study are promising in regard to the general implementation of trauma-focused EBTs in active conflict areas. Future studies need to replicate these findings in a randomized controlled study design.engchildrentrauma-focused treatmentUkrainewarPTSD150article10.1192/j.eurpsy.2025.10032