Ehrmann, DominicDominicEhrmann0000-0002-5794-5596Hermanns, NorbertNorbertHermanns0000-0002-2903-2677Kulzer, BernhardBernhardKulzerChatwin, HannahHannahChatwinSchmitt, AndreasAndreasSchmittSoeholm, UffeUffeSoeholmAxelsen, Johanne LundagerJohanne LundagerAxelsenBroadley, MelanieMelanieBroadleyHaak, ThomasThomasHaakPouwer, FransFransPouwer2023-06-152023-06-152023https://fis.uni-bamberg.de/handle/uniba/59711Aims People with type 1 diabetes have a higher risk for cardiovascular disease (CVD). Reduced heart rate variability (HRV) is a clinical marker for CVD. In this observational study using continuous HRV measurement across 26 days, we investigated whether psychological stressors (diabetes distress, depressive symptoms) and glycaemic parameters (hypo- and hyperglycaemic exposure, glycaemic variability and HbA1c) are associated with lower HRV in people with type 1 diabetes. Methods Data from the non-interventional prospective DIA-LINK1 study were analysed. At baseline, depressive symptoms and diabetes distress were assessed. Glucose values and HRV were recorded daily for 26 days using continuous glucose monitoring (CGM) and a wrist-worn health tracker respectively. Multilevel modelling with participant as nesting factor was used to analyse associations between day-to-day HRV and diabetes distress, depressive symptoms and CGM-derived parameters. Results Data from 149 participants were analysed (age: 38.3 ± 13.1 years, HbA1c: 8.6 ± 1.9%). Participants with elevated diabetes distress had a significantly lower HRV across the 26 days compared to participants without elevated distress (β = −0.28; p = 0.004). Elevated depressive symptoms were not significantly associated with HRV (β = −0.18; p = 0.074). Higher daily exposure to hyperglycaemia (β = −0.44; p = 0.044), higher average exposure to hypoglycaemia (β = −0.18; p = 0.042) and higher HbA1c (β = −0.20; p = 0.018) were associated with reduced HRV across the 26 days. Sensitivity analysis with HRV averaged across all days corroborated these results. Conclusions Diabetes distress is a clinically meaningful psychosocial stressor that could play a role in the cardiovascular health of people with type 1 diabetes. These findings highlight the need for integrated psychosocial care in diabetes management.engcardiovascular healthdepressiondiabetes distressheart rate variabilitytype 1 diabetes610articleurn:nbn:de:bvb:473-irb-597115