This paper introduces Chresiology, a meta-theoretical framework that redefines concept-driven research by prioritising relational dynamics over determinations of meaning and system allocations. Chresiology shifts focus from asking first ‘What does this concept (or term, sign, symbol) mean?’ or ‘Where does it fit?’ to exploring first ‘How does it connect and relate to others?’. The paper shows how Chresiology provides a scalable framework for advancing interdisciplinary and theoretical inquiry. By temporarily suspending predefined meanings and emphasising use over meaning and system, Chresiology offers a flexible methodology adaptable to both small-scale manual analyses and large-scale computational research. The framework’s core relational tools – vectors, Conditional Possibilities (CPs), and tags – enable researchers to uncover connections and patterns across disciplines, fostering innovative pathways for interdisciplinary analysis. Practical applications, including the exploration of the concepts of ‘trace’ and ‘behaviour’, illustrate its ability to challenge disciplinary boundaries and illuminate previously unrecognised relationships.